Fibrin sealant as a delivery vehicle for cells, antibiotics, growth factors, and painkillers

نویسندگان

چکیده

Fibrin sealant has vast uses in surgical settings for both cellular and noncellular delivery. Some advantages include biocompatibility, ability to support cell attachment, controlled degradation rate. There are many clinical applications, from wound healing improving bone defects being used as an adjunct surgery. It can also serve a suitable delivery vehicle cells, steroids, antibiotics, growth factors, chemotherapeutic agents, painkillers. The composition of fibrin be altered allow release, making it attractive system. Lastly, model with 2 the collagen construct may future application that utilizes This review highlights different painkillers

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fibrin sealant as a carrier for sustained delivery of antibiotics Antibiyotiklerin uzun süreli ilaç salınımı için bir taşıyıcı olarak fibrin yapıştırıcı

Correspondence: Selcuk Kara, Onsekiz Mart University, Faculty of Medicine, Department of Ophthalmology, Çanakkale, Turkey Email: [email protected] Received: 12.08.2013, Accepted: 20.03.2014 Copyright © JCEI / Journal of Clinical and Experimental Investigations 2014, All rights reserved JCEI / 2014; 5 (2): 194-199 Journal of Clinical and Experimental Investigations doi: 10.5799/ahinjs.01.201...

متن کامل

Use of novel fibrin-binding peptides as a delivery vehicle for proteins into fibrin matrices

Statement of Purpose: As the field of tissue engineering develops and we understand how cells respond to their physical and chemical environment, the impetus has been to move away from passive matrices and towards functionalized matrices that will be a better substitute for the tissue that is being replaced. While several synthetic polymer systems have shown promise, fibrin, the natural blood c...

متن کامل

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug.

BACKGROUND CONTEXT Intervertebral discs (IVDs) are attractive targets for local drug delivery because they are avascular structures with limited transport. Painful IVDs are in a chronic inflammatory state. Although anti-inflammatories show poor performance in clinical trials, their efficacy treating IVD cells suggests that sustained, local drug delivery directly to painful IVDs may be beneficia...

متن کامل

Fibrin sealant as an alternative for sutures in periodontal surgery.

The trial compared wound healing clinically, histologically and morphometrically after the use of fibrin sealant and sutures for periodontal flap closure. Ten patients were selected for this split-mouth randomized controlled clinical trial. On the test site fibrin sealant (F) was applied for flap closure after periodontal flap surgery (n = 10) and on the control site sutures (S) were used (n = ...

متن کامل

A review of bioceramics and fibrin sealant.

This review focuses on bone substitute composites made by mixing ceramic biomaterials with fibrin sealants. Different biomaterials such as coral, bone-derived materials, bioactive glass ceramics, and synthetic calcium phosphate have been mixed with fibrin sealant, resulting in a combination of the biological properties of the two components. This type of association has not produced identical r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of applied biotechnology & bioengineering

سال: 2023

ISSN: ['2572-8466']

DOI: https://doi.org/10.15406/jabb.2023.10.00328